Nanoscale structures at interfaces formed by lipids and from polymer/surfactant mixtures - deeper understanding provided by large-scale facilities
24. Juni 14:30 - 15:30
- The deposition to form soft matter nano-scale structures at interfaces is a delicate balance...
A measurement of the antineutrino spectrum of the fission products of U238
01. Juli 14:30 - 15:30
- In the last years, antineutrinos from nuclear reactors helped todetermine the parameters in the...
Implementation of a Longitudinal NRSE option for RESEDA at FRM II
15. Juli 14:45 - 15:45
- Longitudinal NRSE (lNRSE) has the possibilities to extend the accesible dynamic range of both NSE...
Seminar: Macromolecular crystallography at the European Spallation Source
The structure determination of biological macromolecules by X-ray crystallography is a key technique in biochemistry and widely applied in the pharmaceutical industry as well. However, the positions of hydrogen atoms – often crucial for understanding the biological function – can generally not be determined by X-ray crystallography. Neutron macromolecular crystallography is the most unambiguous method for locating the hydrogens, but it remains technically far more challenging due to the low brilliance of the available neutron sources and has therefore been applied only to relatively few systems.
The ESS long pulse spallation source is particularly well suited for macromolecular crystallography, where only modest time-of-flight resolution is required. We aim to routinely resolve unit cells with 100-150 Å edges and collect data to ~1-8 Å dmin from crystals of 0.01-0.1 mm3 volume. We are currently planning a time-of-flight quasi-Laue diffractometer 156 m from the target using a ~1.8 Å wavelength band centered at 2.4 Å. We will also provide relevant supporting facilities such a s perdeuteration and crystallization with appropriate access modes.
- Physics HS3
- Garching, Garching, Deutschland
- Dr. E. Oksanen, ESS, Lund, Sweden
- TUM/FRM II